The school notably had Peter Parker and his best friend Ned Leeds as students. It also had an Academic Decathlon Team managed by Roger Harrington and led by Liz Toomes, as well as its own TV show hosted by Jason Ionello and Betty Brant. Parker took advantage of the school's equipment for his Spider-Man activity, using the chemistry labs to synthesize his Synthetic Webbing and hiding his homemade suit behind a series of lockers. In 2016, due to his activities as Spider-Man, Parker quit the school's marching band and robotics lab's club. He also left the Academic Decathlon team.

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